Protective Effect of a Standardized Fraction from Vitex negundo Linn. Against Acetaminophen and Galactosamine Induced Hepatotoxicity in Rodents
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چکیده
منابع مشابه
Protective Effect of a Standardized Fraction from Vitex negundo Linn. Against Acetaminophen and Galactosamine Induced Hepatotoxicity in Rodents
The use of Vitex negundo Linn. (Family: verbenaceae) is well documented in ayurveda and traditional Indian system of medicine for variety of diseases and liver ailments. The aim of the study was to investigate liver protective efficacy of a standardized bioactive fraction (SF) from Vitex negundo Linn. against acetaminophen (APAP) and galactosamine (GalN) hepatotoxicity. SF was tested at doses 1...
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The present study investigated the effect of the various fractions of hydromethanolic extract of the leaves of Vitex negundo (Verbenaceae) against ethanol-induced cerebral oxidative stress in rats. Cerebral oxidative stress was induced by the administration of 20% ethanol (5 ml/100 gbw) for a period of 28 days. The petroleum ether (PEF), chloroform (CF), ethylacetate (EAF) and residual (RF) fra...
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BACKGROUND & OBJECTIVES Currently, herbal preparations are clinically used as functional food, food supplements or as add on therapy, which affects the bioavailability and also the net therapeutic potential of co-administered allopathic drugs. Therefore, it is important to assess the interaction among these two classes of drugs. Here we studied the interaction between orally-administered ethano...
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Vitex negundo Linn. belong to family Verbenaceae. It is an important medicinal plant. Literature survey of V. negundo revealed the presence of different classes of natural products including essential oil, triterpenes, diterpenes, sesquiterpenes, lignan, flavonoids, flavones glycosides, iridoid glycosides, and stilbene derivative. The plant is traditionally reported for its use for the treatmen...
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The ethanolic extract obtained from roots of Operculina turpethum (Convolvulaceae) were evaluated for hepatoprotective activity in rats by inducing liver damage by paracetamol. The ethanol extract at an oral dose of 200 mg/kg exhibited a significant protective effect by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and total bili...
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ژورنال
عنوان ژورنال: Biochemistry & Analytical Biochemistry
سال: 2016
ISSN: 2161-1009
DOI: 10.4172/2161-1009.1000267